Electrochemical sensing of dual biomolecules in live cells and whole blood samples: A flexible gold wire-modified copper-organic framework-based hybrid composite.

For clinical research, the precise measurement of hydrogen peroxide (H2O2) and glucose (Glu) is of paramount importance, due to their imbalanced concentrations in blood glucose, and reactive oxygen species (ROS) play a huge role in COVID-19 viral disease. It is critical to construct and develop a simple, rapid, flexible, long-term, and sensitive detection of H2O2 and glucose. In this paper, we have developed a unique morphological structure of MOF(Cu) on a single-walled carbon nanotube-modified gold wire (swnt@gw). Highly designed frameworks with nanotube composites enhance electron rate-transfer behavior while extending conductance and electroactive surface area.The composite sensing system delivers wide linear-range concentrations, low detection limit, and interference-free performance in co-existence with other biomolecules and metal ions. Endogenous quantitative tracking of H2O2 was performed in macrophage live-cells with the help of a strong stimulator lipopolysaccharide.The composite device was effectively utilized for the measurement of H2O2 and glucose in turbid samples of whole blood and milk samples without a pretreatment process. The practical results of biofluids showed favorable voltammetric results and acceptance recovery percentage levels between 97.49 and 98.88%. Finally, a flexible MOF-based hybrid system may provide a suitable detection platform in the construction of electro-biosensors and hold potential promise for clinical-sensory applications.

An assessment on Air Quality in various Polluted Industrialized states of India due to COVID-19

Coronavirus disease 2019 (SARS-CoV-2) is an infectious disease which is caused by the severe acute respiratory syndrome (SARS) coronavirus. It was discovered in the city of Wuhan, China in late December 2019 and was later declared as a pandemic by the World Health Organization (WHO). The first case in India was reported in Kerala state when the affected person had returned from China. As a result, cases started increasing readily to all the surrounding states due to unprotected contact. In this regard, India imposed various lockdown measures to keep the spread of the disease under control by restricting people gatherings. These lockdown measures improved considerably in the air quality of the states/cities, especially in polluted industrial states, and turned out to be an important benefit. This study aims to assess and compare the impact of major air quality parameters (PM2.5, PM10, CO, NOx, Ozone) on Four major polluted Industrial states of India (Gujarat, Rajasthan, Maharashtra and Uttar Pradesh). The timeline taken for this study is taken for three phases namely: Pre-Covid (March to June of 2019);The strongly affected months of wave 1 of Covid (March to June of 2020) and wave 2 of Covid (March to June of 2021). The results highlighted the following trends during the three phases considered in this study. PM 2.5 showed a reduction of almost 35.65 percent during wave 1 and showed an increase of 7.5 percent during wave 2. PM 10 showed a reduction of almost 38.94 percent during wave 1 and showed an increase of 1.25 percent during wave 2. NOx showed a reduction of almost 54.92 percent during wave 1 and showed a reduction of 3.1 percent during wave 2. CO showed a reduction of almost 26.96 percent during wave 1 and showed a reduction of 7.38 percent during wave 2. Ozone showed a reduction of almost 16.76 percent during wave1 and showed a reduction of 38.5 percent during wave 2. © 2022 IEEE.